师资名录

曹旭

长聘教轨副教授

 

邮箱:xcao@sjtu.edu.cn

曹旭,上海交通大学药学院副教授(tenure-track)、课题组组长(PI)、博士生导师,上海市海外高层次引进人才。博士毕业于新加坡国立大学,随后先后在美国斯隆-凯特琳癌症研究中心和希望之城国家医学中心开展博士后研究。研究工作涉及肿瘤学、免疫学、药理学和生物信息学等多学科交叉。前期工作发表在Blood, Science Advances, PNAS,JITC, Redox Biology等(17篇一作论文,含IF>20论文1篇,20>IF>10论文6篇)。

曹旭课题组专注巨噬细胞与肿瘤免疫药理学领域,聚焦肿瘤免疫吞噬和免疫耐受新机制,发现调控新靶标,为创新药物发现和精准免疫治疗奠定基础,满足肿瘤患者未满足的临床需求。

因科研工作需要,课题组正招聘博士后、助理研究员、科研助理,欢迎咨询!
具体研究方向:1. 吞噬作用与肿瘤免疫治疗;2. 免疫耐受与肿瘤微环境调控;3. 巨噬细胞与创新药物发现。
First, co-first and/or co-corresponding authored papers:
1. Zhang W#, Cao X#, Zhong X, Wu H, Shi Y, Feng M, Wang YC, Ann D, Gwack Y, Yuan YC, Shang W, Sun Z. SRC2 controls CD4+ T cell activation via stimulating c-Myc-mediated upregulation of amino acid transporter Slc7a5. Proceedings of the National Academy of Sciences. 2023; 120 (18): e2221352120. (IF = 12.79)

2. Cao X, Wang Y, Zhang W, Zhong X, Gunes GE, Dang J, Wang J, Epstein AL, Querfeld C, Sun Z, Rosen ST, Feng M. Targeting macrophages for enhancing CD47 blockade-elicited lymphoma clearance and overcoming tumor-induced immunosuppression. Blood. 2022; doi: 10.1182/blood.2021013901. (IF=25.476)

3. Cao X#, Chen J#, Li B#, Dang J, Zhang W, Zhong X, Wang C, Raoof M, Sun Z, Yu J, Fakih MG, Feng M. Promoting antibody-dependent cellular phagocytosis for effective macrophage-based cancer immunotherapy. Science Advances. 2022; 8 (11): eabl9171. (IF=14.957)

4. Cao X#, Li B#, Chen J#, Dang J, Chen S, Gunes EG, Xu B, Tian L, Muend Sabina, Raoof M, Querfeld C, Yu J, Rosen ST, Wang Y, Feng M. Effect of cabazitaxel on macrophages improves CD47-targeted immunotherapy for triple-negative breast cancer. J Immunother Cancer., 2021; 9(3): e002022. (IF= 12.469)

5. Cao X, Nie X, Xiong S, Cao L, Wu Z, Moore PK, Bian JS. Renal protective effect of polysulfide in cisplatin-induced nephrotoxicity. Redox Biol. 2018;15:513-21. (IF= 10.787)

6. Cao X#, Cao L#, Zhang W, Lu R, Bian JS, Nie X. Therapeutic potential of sulfur-containing natural products in inflammatory diseases. Pharmacology & Therapeutics, 2020; 107687 (IF= 13.4)

7. Cao L#, Cao X#, Zhou Y, Nagpure BV, Wu ZY, Hu LF, Yang Y, Sethi Gautam, Moore PK, Bian JS. Hydrogen sulfide inhibits ATP-induced neuroinflammation and Abeta1-42 synthesis by suppressing the activation of STAT3 and cathepsin S. Brain Behav Immun. 2018;73:603-14. (IF= 19.227)

8. Cao X, Ding L, Xie ZZ, Yang Y, Whiteman M, Moore PK, Bian JS. A Review of Hydrogen Sulfide Synthesis, Metabolism, and Measurement: Is Modulation of Hydrogen Sulfide a Novel Therapeutic for Cancer? Antioxid Redox Signal. 2019;31(1):1-38. (IF= 7.468)

9. Cao X, Xiong S, Zhou Y, Wu Z, Ding L, Zhu Y, Wood ME, Whiiteman M, Moore PK, Bian JS. Renal Protective Effect of Hydrogen Sulfide in Cisplatin-Induced Nephrotoxicity. Antioxid Redox Signal. 2018;29(5):455-70. (IF= 7.468)

10. Cao X*, Lai SWT, Chen S, Wang S, Feng M*. Targeting tumour-associated macrophages for cancer immunotherapy. Int Rev Cell Mol Biol. 2022; 368, 61-108. (* co-corresponding author; In press; IF= 6.42)

11. Chen J#, Cao X#, Li B#, Zhao Z, Chen S, Lai SWT, Muend SA, Nossa GK, Wang L, Guo W, Ye J, Lee PP, Feng M. Warburg effect is a cancer immune evasion mechanism against macrophage immunosurveillance. Front Immun., 2021; 3815 (IF= 8.786)

12. Cao X, Zhang W, Moore PK, Bian J. Protective Smell of Hydrogen Sulfide and Polysulfide in Cisplatin-Induced Nephrotoxicity. Int J Mol Sci. 2019; 20(2). (IF= 6.208)

13. Cao X, Cao L, Ding L, Bian JS. A New Hope for a Devastating Disease: Hydrogen Sulfide in Parkinson's Disease. Mol Neurobiol. 2018;55(5):3789-99. (IF= 5.682)

14. Cao X, Wu Z, Xiong S, Cao L, Sethi G, Bian JS. The role of hydrogen sulfide in cyclic nucleotide signaling. Biochem Pharmacol. 2018;149:20-8. (IF= 6.1)



15. Cao X, Bian J. The Signaling Interaction Systems of in NO Biology and H2S and Medicine. Gasotransmitters. 2018;12:145. (Book Chapter)

16. Cao X, Bian JS. The Role of Hydrogen Sulfide in Renal System. Front Pharmacol. 2016;7:385. (IF= 5.81)

17. Cao X, Kong CM, Mathi KM, Lim YP, Cacheux-Rataboul V, Wang X. The use of transformed IMR90 cell model to identify the potential extra-telomeric effects of hTERT in cell migration and DNA damage response. BMC Biochem. 2014;15:17. (IF= 4.06)

18. Lu M#, Cao X#, Yang X, Zheng H, Liu N, Jiang Y, Lin D, Chen Y. A diketoreductase exhibits unique renaturation profile from thermal-induced protein unfolding. Amino Acids. 2010;39(2):609-13. (IF= 3.52)
Co-authored papers:
19. Zhang W, Cao X, Zhong X, Wu H, Feng M, Gwack Y, Sun Z. Steroid nuclear receptor coactivator 2 controls immune tolerance by promoting induced Treg differentiation via upregulating Nr4a2. Science Advances. 2022; 8 (24), eabn7662 (IF= 14.957)

20. Sun HJ, Xiong SP, Cao X, Cao L, Zhu MY, Wu ZY, Bian JS. Polysulfide-mediated sulfhydration of SIRT1 prevents diabetic nephropathy by suppressing phosphorylation and acetylation of p65 NF-κB and STAT3. Redox Biology, 2020; 101813 (IF= 10.787)

21. Zhou YB, Zhou H, Li L, Kang Y, Cao X, Wu ZY, Ding L, Sethi Gautam, Bian JS. Hydrogen Sulfide Prevents Elastin Loss and Attenuates Calcification Induced by High Glucose in Smooth Muscle Cells through Suppression of Stat3/Cathepsin S Signaling Pathway. Int J Mol Sci. 2019;20(17). (IF= 6.208)

22. Zhang W, Cao X, Liu SQ. Aroma modulation of vegetable oils-A review. Critical reviews in food science and nutrition. 2019:1-14. (IF= 11.18)

23. Hua F, Wu Z, Yan X, Zheng J, Sun H, Cao X, Bian JS. DR region of Na(+)-K(+)-ATPase is a new target to protect heart against oxidative injury. Sci Rep. 2018;8(1):13100. (IF= 4.996)

24. Shi M, Cao L, Cao X, Zhu M, Zhang X, Wu Z, Xiong S, Xie Z, Yang Y, Chen J, Wong PT, Bian JS. DR-region of Na(+)/K(+) ATPase is a target to treat excitotoxicity and stroke. Cell death & disease. 2018;10(1):6. (IF= 9.685)

25. Zhou H, Ding L, Wu Z, Cao X, Zhang Q, Lin L, Bian JS. Hydrogen sulfide reduces RAGE toxicity through inhibition of its dimer formation. Free Radic Biol Med. 2017;104:262-71. (IF= 7.38)

26. Zhou Y, Wu Z, Cao X, Ding L, Wen Z, Bian JS. HNO suppresses LPS-induced inflammation in BV-2 microglial cells via inhibition of NF-kappaB and p38 MAPK pathways. Pharmacol Res. 2016;111:885-95. (IF= 7.66)
科研奖励:
1. 2018 新加坡国立大学药理学礼来奖章暨最佳博士毕业论文奖;
2. 2019 Atomwise 智能药物筛选研究计划奖;
3. 2020 美国淋巴瘤研究协会博后奖。

科研项目:
1. 2020-2022 美国淋巴瘤研究协会博士后基金。

网站声明|友情链接|联系我们|返回旧版

地址:上海市东川路800号 邮编:200240
© 2020 上海交通大学药学院