学历及经历
2001.9‒2005.6 本科，中国药科大学药学院
2005.9‒2010.6 博士，中国药科大学药学院（导师：姚其正教授）
2010.7‒2013.10 博士后，美国德州大学医学分部（导师：Jia Zhou 教授）
2013.11‒2014.9 助理研究员，中科院上海药物研究所
2014.10‒2019.9 副研究员，硕士研究生导师，中科院上海药物研究所
2019.10‒2020.2 研究员，硕士研究生导师，中科院上海药物研究所
2020.3‒至今 研究员，上海交通大学药学院/张江高等研究院
荣誉及奖励
2022 国家万人计划“青年拔尖人才”
2014 上海市浦江人才计划
2019 赛诺菲-中科院上海生科院优秀青年人才基金奖励
社会及科技协会兼职
上海医药集团长聘教授
上海市药物靶标发现与递送前沿科学研究基地副主任
上海市创新靶标抗体偶联药物重点实验室（筹）副主任
上海市药学会药物化学专委会委员
中国药学会会员，中国化学会会员，中国生物化学与分子生物学会会员

主要从事新靶标药物发现及化学生物学机制研究，作为主要发明人之一研发多个临床前候选新药；其中，抗肿瘤免疫治疗1类新药SOMCL-18-202和抗抑郁1类候选新药MCB-D166实现成果转让，抗肿瘤免疫激动剂ADC候选新药进入临床前研究。累计发表SCI论文90余篇，H-index 32。以第一作者或通讯作者（含共同）J Med Chem、JACS Au，Acta Pharm Sin B、Vita、Signal Transduct Target Ther和Cancer Res等中科院1区期刊发表40多篇。申请国内外专利30余项，主持多项国家基金委和上海市科委科研项目。2027年招收药理、分子与细胞生物学及生物信息学方向硕/博士生。

1. K Wang# , C Ding#, Y Zou#, C Sun#, Q Li#, Y Cai, Q Liu, Z Song, T Chen, X Yang, K Wang，H Qian, F Liu, Q Meng, B Ma, J Li, Z-J Zhu, H Zhou, A Zhang*, D Gao*. LKB1 directly senses glycolytic metabolites to control AMPK activity. Vita 2026, https://doi.org/10.15302/vita.2026.07.0056.
2. He E, Sun J, Wang Z, Fan Y, Song Z, Zhang A*, Ding C*. Discovery of FAP-Targeted Platinum(IV)-Esterified STING Agonist as Small-Molecule Dual Prodrug Conjugates for Tumor-Specific Metalloimmunotherapy. JACS Au. 2026 Jun 18;6(7):3877-3888.
3. Liu WM, Xu JH, Ding CY*, Zhang A*. PGK1 epigenetically silences STING via DNMT1 and its knockdown synergizes with STING agonists in pancreatic cancer. Acta Pharmacol Sin. 2026 Sep;47(9):2603-2618.
4. Xue Yu-Xiao, Chen Yi-Jun, Qin Mei-Zhen, Shang Fan-Fan, Lu Yi-Ting, Sun Yu-Hao, Bian Liu-Guan*, Zhang Ao*, Yu Yang*, Ding Chun-Yong*. Microglial STING activation promotes neuroinflammation and pathological changes in experimental mice with intracerebral haemorrhage. Acta Pharmacol Sin. 2025 Apr 8. doi: 10.1038/s41401-025-01540-8.
5. Yang Shanlin, Ma Jing, He Ende, Xiong Zhi, Fan Yiming, Ding Chunyong*, Zhang Ao*. Construction of a single-molecule Pt(IV)-centered CAIX-directing STING agonist conjugate as potential metalloimmunotherapy for tumor. Chemical Engineering Journal, 2025, 511, 162042.
6. Li Yang, Zhu Yuyuan, Shang FF, Xu Ling, Jiang Defang, Sun Bin, Zhang Lei, Luo Cheng, Zhang Ao, Zhang Hao*, Ding Chunyong*. Discovery of Urea Derivatives of Celastrol as Selective Peroxiredoxin 1 Inhibitors against Colorectal Cancer Cells. J Med Chem. 2024 67(9):7176-7196.
7. Shang FanFan, Lu Qing, Lin Tailiang, Pu Miaoxia, Xiao Ruoxuan, Liu Wanmei, Deng Hao, Guo Hongyan, Quan Ze-Shan, Ding Chunyong*, Shen Qing-Kun*. Discovery of Triazolyl Derivatives of Cucurbitacin B Targeting IGF2BP1 against Non-Small Cell Lung Cancer. J Med Chem. 2023 Sep 28;66(18):12931-12949.
8. Ding, Chunyong*,#; Du, Mengyan#; Xiong, Zhi#; Wang, Xue#; Li, Hongji; He, Ende; Li, Han; Dang, Yijing; Lu, Qing; Li, Shicong; Xiao, Ruoxuan; Xu, Zhiai; Jing, Lili*;, Deng, Liufu; Wang, Xiyuan; Geng, Meiyu; Xie, Zuoquan*; Zhang Ao*. Photochemically controlled activation of STING by CAIX-targeting photocaged agonists to suppress tumor cell growth. Chem Sci, 2023, 14(22):5956-5964.
9. Xu, Heng#; Zhao, Hongfang#; Ding, Chunyong#; Jiang, Defang; Zhao, Zijie; Li, Yang; Ding, Xiaoyu; Gao, Jing; Zhou, Hu; Luo, Cheng; Chen, Guoqiang; Zhang, Ao*; Xu, Ying*; Zhang, Hao*. Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1, Signal Transduct Target Ther, 2023, 8(1):51.
10. Wang, Tian-Xiang; Duan, Kun-Long; Huang, Zi-Xuan; Xue, Zi-An; Liang, Jun-Yun; Dang, Yongjun; Zhang, Ao; Xiong, Yue; Ding, Chunyong*; Guan, Kun-Liang; Yuan, Hai-Xin*. Tanshinone functions as a coenzyme that confers gain of function of NQO1 to suppress ferroptosis, Life Sci Alliance, 2022, 6(1): e202201667.
11. Zhu Q#, Sun F#, Li T, Zhou M, Ye J, Ji A, Wang H*, Ding C*, Chen H, Xu Z*, Yu H*. Engineering oxaliplatin prodrug nanoparticles for second near Infrared fluorescence imaging-guided immunotherapy of colorectal cancer. Small 2021, 17(13):e2007882.
12. Tan J#, Wu B#, Chen T, Fan C, Zhao J, Xiong C, Feng C, Xiao R, Ding C*, Tang W*, Zhang A*. Synthesis and Pharmacological Evaluation of Tetrahydro-γ-carboline Derivatives as Potent Anti-inflammatory Agents Targeting Cyclic GMP-AMP Synthase. J. Med. Chem. 2021 Jun 10;64(11):7667-7690.
13. Ding C., Song Z., Shen A., Chen T., Zhang A.* “Small molecules targeting the innate immune cGAS‒STING‒TBK1 signaling pathway.” Acta Pharm. Sin. B, 2020, 10(12):2272-2298.
14. Xiao R.#, Ding C.#, Zhu H., Liu X., Gao J., Liu Q., Lu D., Zhang N.*, Zhang A.*, Zhou H.* “Suppression of asparagine synthetase enhances the antitumor potency of ART and artemalogue SOMCL-14-221 in non-small cell lung cancer.” Cancer Lett. 2020, 475, 22-33.
15. Dang Y., Wang F., Li L., Lai Y., Xu Z.*, Xiong Z., Zhang A., Tian Y., Ding C.*, Zhang W.*. “An activatable near-infrared fluorescent probe for methylglyoxal imaging in Alzheimer's disease mice.” Chem. Commun. 2020, 56, 707-710.
16. Ding C.*,#, Wang F.#, Dang Y.#, Xu Z.*, Li L., Lai Y., Yu H., Luo Y., Huang R., Zhang A., Zhang W.*. “Imaging tumorous methylglyoxal by an activatable near-infrared fluorescent probe for monitoring glyoxalase 1 activity.” Anal. Chem. 2019, 91, 15577-15584.
17. Ding C.#, Chen H.#, Liang B., Jiao M., Liang G.*, Zhang A.* “Biomimetic synthesis of the natural product salviadione and its hybrids: discovery of tissue-specific anti-inflammatory agents for acute lung injury.” Chem Sci. 2019, 10, 4667-4672.
18. Ding C. #, Tian Q. #, Li J., Jiao M., Song S., Wang Y.*, Miao Z.-H.*, Zhang A.* “Structural modification of natural product tanshinone I leading to discovery of novel nitrogen-enriched derivatives with enhanced anticancer profile and improved drug-like properties.” J. Med. Chem. 2018, 61, 760-776.
19. Wang F., Yu S., Xu Z.*, Li L., Dang Y., Xu X., Luo Y., Cheng Z., Yu H., Zhang W., Zhang A., Ding C.*. “Acid-promoted D-A-D type far-red fluorescent probe with high photostability for lysosomal nitric oxide imaging.” Anal Chem. 2018, 90, 7953-7962.
20. Li R.,# Ding C.,# Zhang J.,# Xie M., Park D., Ding Y., Chen G., Zhang G., Gilbert-Ross M., Zhou W., Marcus A. I., Sun S. Y., Chen Z. G., Sica G. L., Ramalingam S. S., Magis A. T., Fu H., Khuri F. R., Curran W. J., Owonikoko T. K., Shin D. M., Zhou J.*, Deng X.* “Modulation of bax and mTOR for cancer therapeutics.” Cancer Res. 2017, 77, 3001-3012.

主要研究成果：
（1）建立“一锅多步”串联环化反应，实现Salviadione的首次仿生合成，巧妙运用仿生杂合策略，获得肺组织特异性分布的抗急性肺损伤候选药物，并揭示潜在作用靶标与机制，为开发安全、有效的急性肺损伤治疗药物提供新结构和新靶标机制（Chem Sci 2019）。
（2）突破丹参酮结构改造的传统思路，首次实现四环骨架的氮杂化修饰，获得成药性和药效显著改善的全新结构衍生物（J Med Chem 2018）；并揭示其直接作用靶标和多通路协同的抗肿瘤机制，推动丹参酮类天然产物在抗肿瘤领域的研究与开发（Biochem Pharmacol 2018）。
（3）通过螺环/稠环化策略，获得抗肿瘤活性显著提高的全新青蒿素衍生物（Eur J Med Chem 2015）；利用定量比较蛋白组学等手段，阐明内质网应激诱导的抗肿瘤作用机制，并首次揭示抗肿瘤活性与关键节点蛋白ASNS的相关性，为与ASNS抑制剂的联合用药提供重要依据（Cancer Lett 2020）。
（4）发展了一系列立体和区域选择性化学修饰方法，实现对复杂结构天然产物冬凌草甲素的精准结构改造，为基于该天然产物的药物化学生物学研究开辟新的化学空间（J Med Chem 2013, 56, 5048; J Med Chem 2013, 56, 8814; Org Lett 2013）。
（5）干扰素刺激因子STING是目前肿瘤免疫治疗的前沿热点，但尚无能够口服的小分子激动剂进入临床。通过对天然产物衍生物库筛选和基于靶标结构的药物设计，获得口服有效的非环核苷STING小分子激动剂，并实现成果转让，该候选药物有望通过激活机体天然免疫实现肿瘤的治疗，克服目前PD1/PDL1抗体仅对部分“热”肿瘤有效的局限（Acta Pharm Sin B 2020）。
（6）首次基于D-A-D型苯并噻二唑光电材料结构骨架，构建一系列靶向疾病分子标志物的智能响应型荧光探针，为基于分子功能可视化的肿瘤、炎症和老年痴呆等疾病的诊断、药物作用机制和疗效评估及预后判定奠定基础。主要包括：
a. 构建溶酶体靶向的比率型远红外NO探针，为研究溶酶体NO与炎症等疾病的关系及抗炎药物的疗效监控提供可视化工具 (Anal Chem 2018)。
b. 发展首个体内外检测肿瘤MGO的高性能近红外荧光探针，不仅能原位荧光检测GLO1代谢酶活性，还可对GLO1抑制剂进行可视化筛选和疗效评估（Anal Chem 2019），为阐明肿瘤糖酵解调控机制奠定基础。
c. 利用MGO近红外荧光探针，首次从分子影像学角度证实AD小鼠脑中MGO含量高于野生型，为阐明MGO在AD发生发展中的角色提供影像学证据 (ChemComm 2020)。