师资队伍

孙磊

副研究员

 

电话:021-34207424
邮箱:sunlei_vicky@sjtu.edu.cn
主页:联系地址:药学院7-214

孙磊:女,博士、副研究员、博士生导师。2009年获中国科学院上海生命科学学院博士学位;2009-2011在葛兰素史克中国研发有限公司从事博士后、科学家研究工作;2014-2015在美国伊利诺伊大学医学院微生物与免疫学系从事访问学者的研究工作。2011年进入上海交通大学药学院工作至今。研究方向主要是固有免疫应答与炎症性疾病调控机制的研究以及抗炎、肿瘤免疫药理,力求系统全面地从分子、细胞以及整体动物水平阐明难治性炎症疾病和肿瘤的发病机理与分子机制。目前已发表SCI收录研究论文30余篇,其中包括Pharmacological Research,Cell Host & Microbe, Journal of Immunology, Nature communication等高影响因子专业期刊。主持3项国家自然科学基金,1项教育部基金,并参与了多项国家级科研项目等。获“第十二届全国抗炎免疫药理学学术交流会”青年论文三等奖,上海交通大学“晨星青年学者”奖励计划,及上海交通大学李兰馨青年教师奖励基金。

学术兼职情况:
1. 中国药理学会抗炎免疫药理专委会青年委员会委员
2. 中国免疫学会会员
3. 上海药学会会员
4.上海免疫学会会员

教学情况:
1.研究生《免疫药理学》
2.本科生《微生物学与免疫学》
1) 固有免疫细胞应答机制与慢性炎症性疾病
2) 抗炎及肿瘤免疫药理。
已发表SCI研究论文:
1. Q. Liang, W. Y. Cai, Y. X. Zhao, H. B. Xu, H. R. Tang, D. J. Chen, F. Qian*, L. Sun*. Lycorine ameliorates bleomycin-induced pulmonary fibrosis via inhibiting NLRP3 inflammasome activation and pyroptosis. Pharmacol Res. 2020 Aug;158:104884. (corresponding author)
2. X. L. Li, C. X. Ye, M. Mulati, L. Sun*, F. Qian*. Ellipticine blocks synergistic effects of IL-17A and TNF-α in epithelial cells and alleviates severe acute pancreatitis-associated acute lung injury. Biochem Pharmacol. 2020 Jul;177:113992. (corresponding author)
3. Lei Sun, Qiong Wu, Yunjuan Nie, Ni Cheng, Rui Wang, Gang Wang, Dan Zhang, Huiqion He, Richard D. Ye and Feng Qian*, A Role for MK2 in Enhancing Neutrophil-Derived ROS Production and Aggravating Liver Ischemia/Reperfusion Injury. Frontiers in Immunology, 2018 Nov 13, 9, 2610
4. Ziyan Zhu, Lei Sun*, Rui Hao, Hongchao Jiang, Feng Qian, Richard D. Ye. Nedd8 modification of Cullin-5 regulates lipopolysaccharide-induced acute lung injury. American Journal of Physiology - Lung Cellular and Molecular Physiology. 2017 July 1; Vol. 313 no. 1, L104-L114 (corresponding author)
5. MLN4924 protects against interleukin-17A-induced pulmonary inflammation by disrupting ACT1-mediated signaling. Rui Hao, Yunduan Song, Runsheng Li, Yaxian Wu, Xinyi Yang, Xiaozong Li, Feng Qian, Richard D. Ye, Lei Sun. American Journal of Physiology - Lung Cellular and Molecular Physiology. 2019, April Accepted. (corresponding author)
6. X. Y. Yang, R. S. Li, L. Xu, F. Qian*, L. Sun*. Serum amyloid A3 is required for caerulein-induced acute pancreatitis through induction of RIP3-dependent necroptosis. Immunol Cell Biol. 2021 Jan;99(1):34-48. (corresponding author)
7. J. Wang#, L. Sun#, Y. J. Nie, S. X. Duan, T. Zhang, W. W. Wang, R. D. Ye, S. W. Hou*, F. Qian*. Protein Kinase C δ (PKCδ) Attenuates Bleomycin Induced Pulmonary Fibrosis via Inhibiting NF-κB Signaling Pathway. Front Physiol. 2020 Apr 22;11:367. (first author)
8. L. N. Huang#, L. Sun#, L. M. Liu, H. H. Zhang, Z. B. Liang, Y. Rui, J. F. Hu, Y. Zhang, J. W. Christman and F. Qian: p38alpha MAP kinase promotes asthmatic inflammation through modulation of alternatively activated macrophages. J Mol Cell Biol, 11(12), 1095-1097 (2019)。(first author)
9. D. Zhang, X. Li, Y. Hu, H. Jiang, Y. Wu, Y. Ding, K. Yu, H. He, J. Xu, L. Sun* and F. Qian*: Tabersonine attenuates lipopolysaccharide-induced acute lung injury via suppressing TRAF6 ubiquitination. Biochem Pharmacol, 154, 183-192 (2018) (corresponding author)
10. Y. D. Song, X. Z. Li, Y. X. Wu, Y. Shen, F. F. Liu, P. P. Gao, L. Sun and F. Qian: Emodin alleviates alternatively activated macrophage and asthmatic airway inflammation in a murine asthma model. Acta Pharmacol Sin, 39(8), 1317-1325 (2018) (corresponding author)
11. Yunjuan Nie#, Lei Sun#, Yaxian Wu, Yaoyao Yang, Jun Wang, Huiqiong He, Yudong Hu, Yanhua Chang, Qing Liang, Jianwei Zhu, Richard D. Ye, John W. Christman and Feng Qian*. AKT2 Regulates Pulmonary Inflammation and Fibrosis via Modulating Macrophage Activation. Journal of Immunology. June 1, 2017, 198 (11) 4470-4480. (co-first author)
12. Ziyan Zhu, Lili Wang, Rui Hao, Bo Zhao, Lei Sun*, Richard D. Ye*. A cullin-5-TRAF6 interaction promotes TRAF6 polyubiquitination and lipopolysaccharide signaling. Journal of Immunology. 2016 July 1;197 (1):21-26. (co-corresponding author)
13. Ling Kong*, Lei Sun*, Hong-Xin Zhang, Qin Liu, Ye Liu, Lin-Hua Qin, Guo-Jun Shi, Jun-Hao Hu, A-Jing Xu, Yue-Ping Sun, Dang-Sheng Li, Yu-Fang Shi, Jing-Wu Zang, Jiang Zhu, Zhu Chen, Zhu-Gang Wang, Bao-Xue Ge. An essential role for RIG-I in Toll-like receptor-stimulated phagocytosis. Cell Host &Microbe. 2009 Aug 20;6(2): 150-61.(* co-first author)
14. Ming-Can Yu, Liu-Li Su, Lin Zou, Ye Liu, Na Wu, Ling Kong, Zi-Heng Zhuang, Lei Sun, Hai-Peng Liu, Jun-Hao Hu, Dang-Sheng Li, Jack L Strominger, Jing-Wu Zang, Gang Pei, Bao-Xue Ge. An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells. Nat Immunol. 2008 Aug;9(8):898-907.
15. PLCβ2 negatively regulates the inflammatory response to virus infection by inhibiting phosphoinositide-mediated activation of TAK1.Lin Wang, Yilong Zhou, Zijuan Chen, Lei Sun, Juehui Wu, Haohao Li, Feng Liu, Fei Wang, Chunfu Yang, Juhao Yang, Qibin Leng, Qingli Zhang, Ajing Xu, Lisong Shen, Jinqiao Sun, Dianqing Wu, Caiyun Fang, Haojie Lu, Dapeng Yan, and Baoxue Ge. Nat Commun. 2019; 10: 746.
16. Lei Sun, Richard D.Ye. Serum amyloid A1: Structure, function and gene polymorphism. Gene. 2016 May 25;583(1):48-57.
17. Lei Sun, Huibin Zhou, Ziyan Zhu, Qian Yan, Lili Wang, Qing Liang, Richard D. Ye. Ex vivo and in vitro effect of Serum Amyloid A in the induction of macrophage M2 markers and efferocytosis of apoptotic neutrophils. Journal of Immunology. 2015 May 15;194(10):4891-900.
18. Qian Yan*, Lei Sun*, Ziyan Zhu, Lili Wang, Shuqin Li, Richard D.Ye. Jmjd3-mediated epigenetic regulation of inflammatory cytokine gene expression in serum amyloid A-stimulated macrophages. Cell Signal. 2014 Sep;26(9):1783-91. (* co-first author)
19. Lei Sun, Ziyan Zhu, Ni Cheng, Richard D. Ye. Serum amyloid A induces interleukin-33 expression in an IRF7 dependent pathway. Eur J Immunol. 2014 Jul;44(7):2153-64.
纵向基金资助情况:
1、自然科学基金面上项目,主持,2021年1月至2024年12月(82073858):E3泛素连接酶LMO7促进巨噬细胞焦亡增强特发性肺纤维化的机制研究及药物靶标鉴定。
2. 自然科学基金应急管理项目,主持,2018年1月至2018年12月(31741038):Cullin 5在SAA诱导的非感染性炎症中的作用及机制研究。
3. 国家自然科学基金青年基金项目,主持,2013年1月至2015年12月(81202316):2型甲酰肽受体调控M2 型巨噬细胞极化的分子机制以及其在炎症反应中的作用。
4. 教育部博士点专项科研基金新教师基金,主持,2013年1月至2015年12月(20120073120092):血清淀粉样蛋白A(SAA)抑制Th17细胞分化的机制研究及其在炎症性肠部中的作用。

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