师资队伍

李晓波

长聘教授

 

电话:(86)-021-34204806
传真:(86)-021-34204806
邮箱:xbli@sjtu.edu.cn
主页:7号楼301-304室

1997.3 毕业于日本富山医科药科大学,获博士学位
1998.4 中国药科大学从事博士后研究
2000.7 任职于上海交通大学药学院
采用现代化学分离分析技术、分子生物学和代谢组学等手段,进行中药及天然药物活性物质及作用机制、品质评价及质量标准等相关研究,包括
1.中药药效物质及质量标准研究;
2.生药资源评价与保护研究;
近3年主要发表论文(2019-2021)
1. Lijuan Zhao, Ping Ma, Ying Peng, Mengyue Wang, Chongsheng Peng, Yulong Zhang, Xiaobo Li. Amelioration of hyperglycaemia and hyperlipidaemia by adjusting the interplay between gut microbiota and bile acid metabolism: Radix Scutellariae as a case. Phytomedicine, 2021, 83:153477.
2. Li Fan, Ying Peng, Jingwen Wang, Ping Ma, Lijuan Zhao, Xiaobo Li. Total glycosides from stems of Cistanche tubulosa alleviate depression-like behaviors: bidirectional interaction of the phytochemicals and gut microbiota. Phytomedicine, 2021, 83: 153471.
3. Yulong Zhang, Ying Peng, Lijuan Zhao, Guisheng Zhou, Xiaobo Li. Regulating the gut microbiota and SCFAs in the faeces of T2DM rats should be one of antidiabetic mechanisms of mogrosides in the fruits of Siraitia grosvenorii. Journal of Ethnopharmacology 2021, 274 :114033.
4. Yulong Zhang, Guisheng Zhou, Ying Peng, Mengyue Wang, Xiaobo Li. Anti-hyperglycemic and anti-hyperlipidemic effects of a special fraction of Luohanguo extract on obese T2DM rats. Journal of Ethnopharmacology, 2020, 247: 112273.
5. Chongzhi Sun1, Ying Peng1, Yang Wu, Yulong Zhang, Xiaobo Li. The effect of Metapanax delavayi leaf extract on testosterone-induced benign prostatic hyperplasia in rats. Journal of Functional Foods, 2020, 66: 103797.
6. Ying Peng, Shuoying Zhang, Zhiwei Liu, Jia Ji, Chunfu Wu, Jingyu Yang, Xiaobo Li.Gut microbiota and Chinese medicine syndrome: altered fecal microbiotas in spleen (Pi)-deficient patients. Journal of Traditional Chinese Medicine. 2020, 40(1):137-143.
7. Lijuan Zhao, Hongxiang Lou, Ying Peng, Shihong Chen, Li Fan, Xiaobo Li. Elevated levels of circulating short-chain fatty acids and bile acids in type 2 diabetes are linked to gut barrier disruption and disordered gut microbiota. Diabetes Research and Clinical Practice. 2020, 169 : 108418.
8. Ying Zhang, Jinzhao Liu, Mengyue Wang , Chenjie Sun, Xiaobo Li. Five new compounds from Hosta plantaginea flowers and their anti-inflammatory activities. Bioorganic Chemistry. 2020, 95:103494.
9. Peijun Ju, Wenhua Ding, Jianhua Chen, Ying Cheng, Beibei Yang, Lanting Huang, Qiong Zhou, Cuizhen Zhu, Xiaobo Li, Mengyue Wang, Jinghong Chen. The protective effects of Mogroside V and its metabolite 11-oxo-mogrol of intestinal microbiota against MK801-induced neuronal damages. Psychopharmacology, 2020, 237:1011-1026.
10. Yinhuan Hou, Mengyue Wang, Chongzhi Sun, Chongsheng Peng, Ying Zhang, Xiaobo Li. Tunicyclin L, a cyclic peptide from Psammosilene tunicoides: Isolation, characterization, conformational studies and biological activity. Fitoterapia, 2020, 145:104628.
11. MengYue Wang, ZhiBin Zhan, Ying Xiong, Hao Zhang, XiaoBo Li. New cytotoxic constituents in the water-soluble fraction from Momordicae Semen. Natural Product Research, 2020, 34(6):823-829.
12. 胡洁品, 彭颖, 刘峰, 张敏, 彭崇胜, 李晓波. 山楂核抗氧化、抑菌活性物质的筛选和UPLC-Q-TOF/MS分析活性物质的化学成分. 食品科技. 2020, 45(2): 334-340.
13. Min Zhang, Ying Peng, Mengyue Wang, Beibei Gao, Lijuan Zhao, Xiaobo Li. The influence of compatibility of Si-Ni decoction with metabolism in intestinal bacteria on transports of toxic diterpenoid alkaloids from processed aconite root across Caco-2 monolayers. Journal of Ethnopharmacology, 2019 228:164-178.
14. Chongzhi Sun, Yang Wu, Bei Jiang, Ying Peng, Mengyue Wang, Jiaxun Li, Xiaobo Li. Chemical components from Metapanax delavayi leaves and their anti-BHP activities in vitro. Phytochemistry, 2019, 160: 56-60.
15. Xiaomeng Wang1, Ying Peng1, Zhiwei Liu, Shuoying Zhang, Jingyu Yang,Chunfu Wu, Xiabo Li. Aging Gut Microbiota Markers, a Chinese Local Study. International Journal of Gerontology, 2019, 13: 38-44.
16. Renjie Xu1, Ying Peng1, Mengyue Wang, Xiaobo Li. Intestinal Absorption of Isoalantolactone and Alantolactone, Two Sesquiterpene Lactones from Radix Inulae, Using Caco-2 Cells. European Journal of Drug Metabolism and Pharmacokinetics, 2019, 44: 295-303.
17. Mengyue Wang, Zhibin Zhan, Ying Xiong, Ying Zhang, Xiaobo Li. Cytotoxic and anti-inflammatory constituents from Momordica cochinchinensis seeds. Fitoterapia, 2019, 139:104360.
18. Liang Zheng, Mengyue Wang, Zhong Chen, Jincai Hou, Xiaobo Li. Simultaneous quantitation of 13 active components in SimiaoYong'an Decoction using High-performance liquid chromatography with diode array detection. Acta Chromatographica, 2019, 31(3):216–221.
19. Mengyue Wang, Lili Wu, Hao Zhang, Dun Zhu Ci Ren, Tonghua Liu, Xiaobo Li. The antioxidant compounds from Urtica fissa flowers. Chemistry of Natural Compounds, 2019, 55(5):839-842.
20. Lijuan Zhao, Hongxiang Lou, Ying Peng, Shihong Chen, Yulong Zhang, Xiaobo Li. Comprehensive relationships between gut microbiome and faecal metabolome in individuals with type 2 diabetes and its complications. Endocrine, 2019, 66(3):526-537.
21. Beibei Gao1, Ying Peng1, Chongsheng Peng, Yulong Zhang, and Xiaobo Li. A Comparison of characterization and its actions on immunocompetent cells of polysaccharides from Sijunzi decoction. Evidence-Based Complementary and Alternative Medicine, 2019: 9860381.
22. Yang Li, Ying Peng, Ping Ma, Mengyue Wang, Chongsheng Peng, Pengfei Tu, Xiaobo Li. In vitro and in vivo metabolism of Cistanche tubulosa extract in normal and chronic unpredictable stress-induced depressive rats. Journal of Chromatography B, 2019 (1125): 121728.
23. 黄文武, 彭颖, 王梦月, 彭崇胜, 李晓波. 四君子汤及其单味药水煎液对脾虚大鼠肠道菌群的调节作用. 中国实验方剂学杂志, 2019, 25(11): 8-15.
24. 吴阳, 彭颖, 彭崇胜, 管晖, 孙崇智, 李晓波. 青刺尖叶中改善大鼠良性前列腺增生的活性组分筛选. 现代食品科技, 2019, 35(3): 46-51.
主持完成“973”预研、国家科技重大专项“重大新药创制”关键技术课题/候选药物课题、国家“十一五”支撑计划重点课题、“863”、国家自然科学基金重大研究计划课题等科研项目20余项。获教育部“优秀青年教师资助计划”(2002年)、教育部科技进步一等奖(2008年)、中华中医药学会科学技术奖一等奖(2017年)。发表论文150余篇,获专利授权12项,参与编写专著及教材5部。
课题组近期/主要研究成果

(项目/论文/专著/专利等均可)
(一)近3年项目
1. 《从肠脑轴探究四君子汤改善脾气虚“纳少”、“神失”的体内功效物质》,国家自然科学基金面上项目,2020.1-2023.12
2. 《基于前列腺上皮屏障研究荨麻治疗BPH的作用物质基础及其屏障透过机理》,上海自然基金项目,2020.7-2023.7
3. 《补中益气汤经肠道菌群的调控作用治疗脾虚证的分子机制研究》,国家自然科学基金青年项目,2019.1-2021.12
4. 《中药肉苁蓉大品种开发与产业化项目》,国家重点研发计划中医药现代化研究重点专项,2018.1-2021.12
5. 《苦参等大宗中药材的综合利用技术研究》,国家重点研发计划中医药现代化研究重点专项,2018.1-2021.12
6. 《从代谢角度发现罗汉果皂苷抗肥胖型2型糖尿病物质基础及作用机制》,国家自然科学基金面上项目,2017.1-2020.12

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