副主任药师/副研究员 医学博士（硕士生导师）
上海交通大学医学院附属第一人民医院临床药学科主任助理

教育经历：
2011/09-2015/09，上海交通大学，药学，博士
2004/09-2007/07，哈尔滨医科大学药学院，药理学，硕士
1999/09-2004/07，山西医科大学，临床医学，学士
科研与学术工作经历：
2020/5-至今，上海交通大学医学院附属第一人民医院，副主任药师/副研究员
2017/12-2020/5，上海交通大学，副研究员
2010/01－2017/12，上海交通大学，助理研究员
2007/08－2009/12，上海交通大学，研究实习员
主要学术兼职：
担任上海市药学会药物分析专委会委员（秘书）；中国药理学会专业委员会委员；中国医药教育协会老年药学专业委员会委员；《中国药房》青年编委等。

1. 临床药学转化研究
2. 中药临床前研究
3. 中药分子药理学和多组学研究

1. Wu, Z.; Jia, M.; Zhao, W.; Huang, X.; Yang, X.; Chen, D.; Qiaolongbatu, X.; Li, X.; Wu, J.; Qian, F.; Lou, Y.; Fan, G.; et al., Schisandrol A, the main active ingredient of Schisandrae Chinensis Fructus, inhibits pulmonary fibrosis through suppression of the TGF-beta signaling pathway as revealed by UPLC-Q-TOF/MS, network pharmacology and experimental verification. J Ethnopharmacol, 2022: p. 115031.（2022，4.36）
2. L. Zhou, S. Wang, M. Chen, S. Huang, M. Zhang, W. Bao, A. Bao, P. Zhang, H. Guo, Z. Liu, G. Xie, J. Gao, Z. Wu*, Y. Lou*, G. Fan*, Simultaneous and rapid determination of 12 tyrosine kinase inhibitors by LC-MS/MS in human plasma: Application to therapeutic drug monitoring in patients with non-small cell lung cancer, J Chromatogr B Analyt Technol Biomed Life Sci 1175 (2021) 122752.（2020，3.205）
3. Hema Negi ; Siva Bharath Merugu ; Hitesh Bhagavanbhai Mangukiya; Zheqi Li; Bingjie Zhou; Qudsia Sehar; Suchitra Kamle; Fakhar-un-Nisa Yunus; Dhahiri Saidi Mashausi; Zhenghua Wu; Dawei Li , Anterior Gradient-2 Monoclonal Antibody Inhibits Lung Cancer Growth and Metastasis by Upregulating p53 Pathway and Without Exerting Any Toxicological Effects: A Preclinical Study，Cancer Letters, 2019，449，125-134. (2019.5.1)（2019，7.36）
4. Hitesh Bhagavanbhai Mangukiya, Hema Negi, Siva Bharath Merugu, Qudsia Sehar, Dhahiri Saidi Mashausi, Fakhar-Un-Nisa Yunus, Zhenghua Wu, Dawei Li. Paracrine signalling of AGR2 stimulates RhoA function in fibroblasts and modulates cell elongation and migration. Cell Adhesion & Migration. 2019, VOL. 13, NO. 1, 332–344.（2019，3.694）
5. Sehar Qudsia; Siva B. Merugu; Hitesh B. Mangukiya; Negi Hema，Zhenghua Wu, Dawei Li，A novel lentiviral scFv display library for rapid optimization and selection of high affinity antibodies, Biochemical and Biophysical Research Communications, 2018.4.30, 499(1): 71~77.（2018，2.705）
6. H Guo, Q Zhu, X Yu, S B Merugu, H B Mangukiy, N Smith4, Z Li, B Zhang, H Negi, R Rong, K Cheng, Z Wu and D Li, Tumor-secreted anterior gradient-2 binds to VEGF and FGF2 and enhances their activities by promoting their homodimerization. Oncogene, 2017.9.7, 36(36): 5098~5190.（2017，6.854）
7. Zhu Q, Mangukiya HB, Mashausi DS, Guo H, Negi H, Merugu SB, Wu Z, Li D. Anterior Gradient 2 (AGR2) is induced in cutaneous wound and promotes wound healing through its adhesion domain. FEBS J. 2017.7.1, 284(17), 2856-2869.（2017，4.53）
8. Zheqi Li, Qi Zhu1, Lingyun Hu, Hao Chen1, Hema Negi, Zhenghua Wu, Dawei Li, Binding of anterior gradient 2 and estrogen receptor-α: dual critical roles in enhancing fulvestrant resistance and IGF-1-induced tumorigenesis of breast cancer. Cancer letter, 2016.4.12, 377(1): 32-43.（2016，6.375）
9. Zhenghua Wu, Kebin Cheng, Lidan Shi, Zheqi Li, Hema Negi, Guangwei Gao, Suchitra Kamle, Dawei Li，Sal-like protein 2 upregulates p16 expression through a proximal promoter element, Cancer Science, 2015, 106(3): 253-261. （2015，3.896）
10. Zheqi Li, Zhenghua Wu, Hao Chen, Qi Zhu, Guangwei Gao, Lingyun Hu, Hema Negi, Suchitra Kamle and Dawei Li，Induction of anterior gradient2 (AGR2) plays a key role in insulin-like growth factor-1 (IGF-1)-induced breast cancer cell proliferation and migration, Medical Oncology, 2015.5.10, 32(6)：577-588.（2015，2.486）
11. Zheqi Li, Lingyun Hu, Hao Chen, Qi Zhu, Zhenghua Wu and Dawei Li, Anterior gradient 2 is a binding stabilizer of HIF-1α that enhances CoCl2-induced doxorubicin resistance in breast cancer cells, Cancer Science, 2015.6.17, 106(8): 1041-1049. （2015，3.896）

主持国家自然科学基金、上海市2022年度“科技创新行动计划”生物医药科技支撑专项项目、吴阶平医学基金会临床科研专项资助基金，松江区科技攻关项目等多个科研项目；获国内、国际授权专利5项；以通讯或第一作者在SCI期刊上发表论文10余篇。
获得日本癌症协会Cancer Science Young Scientists Award、浦江DMPK论坛优秀奖、上海药学会临床药学分会优秀成果奖，上海药理学会年会优秀成果奖、上海市药学会论文一等奖等。