行业导师

武正华

行业导师

 

电话:021-36123711
邮箱:wuzhenghua526@163.com

副主任药师/副研究员 医学博士(硕士生导师)
上海交通大学医学院附属第一人民医院临床药学科主任助理

教育经历:
2011/09-2015/09,上海交通大学,药学,博士
2004/09-2007/07,哈尔滨医科大学药学院,药理学,硕士
1999/09-2004/07,山西医科大学,临床医学,学士
科研与学术工作经历:
2020/5-至今,上海交通大学医学院附属第一人民医院,副主任药师/副研究员
2017/12-2020/5,上海交通大学,副研究员
2010/01-2017/12,上海交通大学,助理研究员
2007/08-2009/12,上海交通大学,研究实习员
主要学术兼职:
担任上海市药学会药物分析专委会委员(秘书);中国药理学会专业委员会委员;中国医药教育协会老年药学专业委员会委员;《中国药房》青年编委等。
1. 临床药学转化研究
2. 中药临床前研究
3. 中药分子药理学和多组学研究
1. Wu, Z.; Jia, M.; Zhao, W.; Huang, X.; Yang, X.; Chen, D.; Qiaolongbatu, X.; Li, X.; Wu, J.; Qian, F.; Lou, Y.; Fan, G.; et al., Schisandrol A, the main active ingredient of Schisandrae Chinensis Fructus, inhibits pulmonary fibrosis through suppression of the TGF-beta signaling pathway as revealed by UPLC-Q-TOF/MS, network pharmacology and experimental verification. J Ethnopharmacol, 2022: p. 115031.(2022,4.36)
2. L. Zhou, S. Wang, M. Chen, S. Huang, M. Zhang, W. Bao, A. Bao, P. Zhang, H. Guo, Z. Liu, G. Xie, J. Gao, Z. Wu*, Y. Lou*, G. Fan*, Simultaneous and rapid determination of 12 tyrosine kinase inhibitors by LC-MS/MS in human plasma: Application to therapeutic drug monitoring in patients with non-small cell lung cancer, J Chromatogr B Analyt Technol Biomed Life Sci 1175 (2021) 122752.(2020,3.205)
3. Hema Negi ; Siva Bharath Merugu ; Hitesh Bhagavanbhai Mangukiya; Zheqi Li; Bingjie Zhou; Qudsia Sehar; Suchitra Kamle; Fakhar-un-Nisa Yunus; Dhahiri Saidi Mashausi; Zhenghua Wu; Dawei Li , Anterior Gradient-2 Monoclonal Antibody Inhibits Lung Cancer Growth and Metastasis by Upregulating p53 Pathway and Without Exerting Any Toxicological Effects: A Preclinical Study,Cancer Letters, 2019,449,125-134. (2019.5.1)(2019,7.36)
4. Hitesh Bhagavanbhai Mangukiya, Hema Negi, Siva Bharath Merugu, Qudsia Sehar, Dhahiri Saidi Mashausi, Fakhar-Un-Nisa Yunus, Zhenghua Wu, Dawei Li. Paracrine signalling of AGR2 stimulates RhoA function in fibroblasts and modulates cell elongation and migration. Cell Adhesion & Migration. 2019, VOL. 13, NO. 1, 332–344.(2019,3.694)
5. Sehar Qudsia; Siva B. Merugu; Hitesh B. Mangukiya; Negi Hema,Zhenghua Wu, Dawei Li,A novel lentiviral scFv display library for rapid optimization and selection of high affinity antibodies, Biochemical and Biophysical Research Communications, 2018.4.30, 499(1): 71~77.(2018,2.705)
6. H Guo, Q Zhu, X Yu, S B Merugu, H B Mangukiy, N Smith4, Z Li, B Zhang, H Negi, R Rong, K Cheng, Z Wu and D Li, Tumor-secreted anterior gradient-2 binds to VEGF and FGF2 and enhances their activities by promoting their homodimerization. Oncogene, 2017.9.7, 36(36): 5098~5190.(2017,6.854)
7. Zhu Q, Mangukiya HB, Mashausi DS, Guo H, Negi H, Merugu SB, Wu Z, Li D. Anterior Gradient 2 (AGR2) is induced in cutaneous wound and promotes wound healing through its adhesion domain. FEBS J. 2017.7.1, 284(17), 2856-2869.(2017,4.53)
8. Zheqi Li, Qi Zhu1, Lingyun Hu, Hao Chen1, Hema Negi, Zhenghua Wu, Dawei Li, Binding of anterior gradient 2 and estrogen receptor-α: dual critical roles in enhancing fulvestrant resistance and IGF-1-induced tumorigenesis of breast cancer. Cancer letter, 2016.4.12, 377(1): 32-43.(2016,6.375)
9. Zhenghua Wu, Kebin Cheng, Lidan Shi, Zheqi Li, Hema Negi, Guangwei Gao, Suchitra Kamle, Dawei Li,Sal-like protein 2 upregulates p16 expression through a proximal promoter element, Cancer Science, 2015, 106(3): 253-261. (2015,3.896)
10. Zheqi Li, Zhenghua Wu, Hao Chen, Qi Zhu, Guangwei Gao, Lingyun Hu, Hema Negi, Suchitra Kamle and Dawei Li,Induction of anterior gradient2 (AGR2) plays a key role in insulin-like growth factor-1 (IGF-1)-induced breast cancer cell proliferation and migration, Medical Oncology, 2015.5.10, 32(6):577-588.(2015,2.486)
11. Zheqi Li, Lingyun Hu, Hao Chen, Qi Zhu, Zhenghua Wu and Dawei Li, Anterior gradient 2 is a binding stabilizer of HIF-1α that enhances CoCl2-induced doxorubicin resistance in breast cancer cells, Cancer Science, 2015.6.17, 106(8): 1041-1049. (2015,3.896)
主持国家自然科学基金、上海市2022年度“科技创新行动计划”生物医药科技支撑专项项目、吴阶平医学基金会临床科研专项资助基金,松江区科技攻关项目等多个科研项目;获国内、国际授权专利5项;以通讯或第一作者在SCI期刊上发表论文10余篇。
获得日本癌症协会Cancer Science Young Scientists Award、浦江DMPK论坛优秀奖、上海药学会临床药学分会优秀成果奖,上海药理学会年会优秀成果奖、上海市药学会论文一等奖等。

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