科研团队
功能化DDS及新药研发课题组 G
  • 简介

    组长简介:

    邱明丰,男,研究员、博士生导师、博士,现任副院长、上海交通大学-西双版纳州傣医药研究中心主任、功能化DDS及新药研发课题组组长。2001年于成都中医药大学获博士学位,20039月从新加坡回国任职至今。长期从事中药、民族药(傣药)领域的科研与教学,致力中药、民族药(傣药)缓释与速释新型制剂及其整体疗效综合评价方法的研究。主持课题20项、参加科研项目21项(含国家自然科学基金4项、国家九五攻关、国际合作项目等),在EJPSJEPJPBAECAMJAFCJPR、《中国中药杂志》、《中草药》、《中成药》等杂志上发表论文126篇(含SCI 40篇,高被引论文1篇,单篇被引过百次并被Nature中文章作为亮点引用1篇),编写著作教材11部(含教材3部、主编1部、副主编5部),申请专利32项(授权9项)。主讲本科生课程4门、研究生课程3门。教学获奖近10项,包括上海交通大学首批晨星学者奖励、教学成果特等奖、优秀教师二等奖等。科研获奖6项,包括中华中医药学会科技二等奖、市政府决策咨询成果二等奖等;联合研发的1类、6类和8类新药获临床批件。指导硕士生59名、博士留学生2名,学生获奖18人次(包括研究生国家奖学金、上海市优秀毕业生、校三好标兵等)。

    学术兼职,包括滇西应用技术大学学术委员会委员、科技部国际合作司评审专家、教育部高等学校科学技术同行评议专家、国家自然科学基金委员会同行评议专家、世界中医药学会联合会中药药剂专业委员会理事、中国民族医药学会傣医药分会常务理事、中华中医药学会中成药分会委员、上海市药学会中药专业委员会委员、《中华医学实践杂志》常务编委、《转化医学电子杂志》编委等。

    联系方式:86-21-34204052mfqiu@sjtu.edu.cn

  • 成员简介

    苏靖,男,副教授、硕士生导师、美国加州大学圣地亚哥分校访问学者,2008年于沈阳药科大学药物获得化学博士学位。
  • 研究方向/领域

    1、生物仿生膜系统载药(天然药物、生物大分子、化学药物)研究
    2、中药、民族药(傣药)和天然药物新药研究
    3、可降解药用材料及其功能化研究

  • 主要成果/奖励

    主持课题20项、参加科研项目21项(含国家自然科学基金4项、国家九五攻关、国际合作项目等),在EJPS、JEP、JPBA、ECAM、JAFC、JPR、《中国中药杂志》、《中草药》、《中成药》等杂志上发表论文126篇(含SCI 40篇,高被引论文1篇,单篇被引过百次1篇),编写著作教材11部(含教材3部、主编1部、副主编5部),申请专利32项(授权9项)。科研获奖6项,包括中华中医药学会科技二等奖、市政府决策咨询成果二等奖等。
  • 著作/论文/专利

    一、著作
    1. 现代药物研发实践,上海:上海交通大学出版社,2015年9月,主编
    2. 中药制剂工艺技术图表解,北京:人民卫生出版社,2011年1月;ISBN978-7-117-13698-3/R.13699,副主编
    3. 医学代谢组学,上海:上海科学技术出版社,2011年1月,ISBN978-7-5478-0492-6,编委
    4. 中药药剂学(全国普通高等教育中医药类精编教材),上海:上海科学技术出版社,2008年8月第1版,ISBN978-7-5323-9259-9,副主编
    5. 傣医常用名词术语解释,昆明:云南民族出版社,2008年12月第1版,ISBN978-7-5637-4250-2,编委
    6. 傣医方剂学(21世纪傣医本科教育规划教材),北京:中国中医药出版社,2007年11月第1版,ISBN978-7-80231-326-2,副主编
    7. 云南省中药材标准2005年版第三册·傣族药,昆明:云南科技出版社,2007年12月第1版,ISBN978-7-5416-2746-0,副主任委员
    8. 中药新制剂开发与应用,北京:人民卫生出版社,2006年1月(第三版),编委
    9. 药物控释新剂型,北京:化学工业出版社,2005年4月第1版,ISBN7-5025-6620-1/R·269,副主编
    10. 生物资源中活性物质的开发与应用,2005年8月第一版,化学工业出版社,副主编
    11. 中药品种品质与化学成分实验(全国高等中医药院校教材),上海:上海科技出版社,2003年3月第1版,ISBN7-5323-6897-1,编委
    二、论文
    1. Xin Ma, Haimiao Zou, Yibin Pan, Jing Su, Yujiao Qiu,Mingfeng Qiu*.Quality assessment of pollen typhae by high-performance liquid chromatography fingerprint, hierarchical cluster analysis, and principal component analysis. Pharmacognosy Magazine, 2019, 15(61): 177.
    2. Xiao Que1, Jing Su1, Pengcheng Guo, Zul Kamal, Enge Xu, Siyu Liu, Jieyu Chen, Mingfeng Qiu*. Study on preparation, characterization and multidrug resistance reversal of red blood cell membrane-camouflaged tetrandrine-loaded PLGA nanoparticles. Drug delivery, 2019, 26(1): 199-207.
    3. Jing Su, Ran Zhang, Yumei Lian, Zul Kamal, Zhongyao Cheng, Yujiao Qiu, Mingfeng Qiu*. Preparation and characterization of erythrocyte membrane-camouflaged berberine hydrochloride (BH)-loaded gelatin nanoparticles. Pharmaceutics. 2019, 11(2): 93.
    4. Xiumei Zhang1, Mingfeng Qiu1, Pengcheng Guo, Yumei Lian, Enge Xu, Jing Su*.Autologous Red Blood Cell Delivery of Betamethasone Phosphate Sodium for Long Anti-Inflammation. Pharmaceutics,2018,10(4)286.
    5. Jing Su,Geyi Liu, Yumei Lian ,Zul Kamal, Xiao Que, Yujiao Qiu,Mingfeng Qiu*. Preparation and Characterization of Erythrocyte Membrane Cloaked PLGA/Arsenic Trioxide Nanoparticles and Its’ in Vitro Anti-tumor Evaluation,RSC Advances.2018,8,20068-20076
    6. Zhongyao Cheng, Yumei Lian, Zul Kamal, Xin Ma, Jianjun Chen, Xinbo Zhou*., Jing Su*. and Mingfeng Qiu*. Nanocrystals Technology for Pharmaceutical Science. Current Pharceutical Design, 2018, 24(21):2497-2507.
    7. Junwei Fang, Liping Wang, Yang Wang, Mingfeng Qiu* and Yongyu Zhang*. Metabolomics combined with pattern recognition and bioinformatics analysis methods for the development of pharmacodynamics biomarkers on live fibrosis. Molecular BioSystems,2017, 13(8): 1575-1583.
    8. Yanan Sun, Jing Su,Geyi Liu, Jianjun Chen, Xiumei Zhang,Ran Zhang,Minhan Jiang,Mingfeng Qiu*. Advances of blood cell-based drug delivery systems. European Journal of Pharmaceutical Sciences.2017,96:115-128.
    9. Xuelan Tang1, Ping Lu1, Mingfeng Qiu1, Jianjun Chen, Lin Ma, Yanan Sun, Feng Zheng, Enge Xu, Jing Sheng and Jing Su. Screening PEGylated polyethylenimine derivatives for safe and efficient delivery of gene materials. RSC Advances.2016,6(108):106316-106326.
    10. Hongmei An, Chen Lin, Chao Gu, Jinjun Chen, Wenxian Sun, Miao Jin, Tianli Zhang, Mingfeng Qiu*, Bing Hu*. Di-Huang-Yi-Zhi herbs attenuate amyloid-induced neurotoxicity in PC12 cells. Experimental and Therapeutic Medicine. 2017, 13(6): 3003-3008.
    11. Junwei Fang, Wenyu Wang, Shujun Sun, Yang Wang, Qianhua Li, Mingfeng Qiu* Yongyu Zhang*. Metabolomics study of renal fibrosis and intervention effect of total aglycone extracts of Scutellaria baicalensis in unilateral ureteral obstruction rats. Journal of Ethnopharmacology. 2016,192:20-29.
    12. Ge Ru,Limei Han,Jin Qing,Jianyong Sheng,Ruixiang Li, Mingfeng Qiu*, Jianxin Wang*. Effects of borneol on the pharmacokinetics of 9-nitrocamptothecin encapsulated in PLGA nanoparticles with different size via oral administration. Drug Delivery.2016,23(9):3417-3423.
    13. Song Xue, Ran Zhang, Jing Su, Xuelan Li, Mingfeng Qiu*, Yingzi Wang*. 27 Fingerprint analysis of Clerodendranthus Spicatus from different regions by high-performance liquid chromatography. Asian Journal of Traditional Medicines,2016,11(1):1-10.
    14. Linjing Zhao, Aihua Zhao, Tianlu Chen, Wenlian Chen, Jiajian Liu, Runmin Wei, Jing Su, Xuelan Tang, Keyi Liu, Ran Zhang, Guoxiang Xie, Jun Panee, Mingfeng Qiu*, Jia Wei*. Global and Targeted Metabolomics Evidences of the Protective Effect of Chinese Patent Medicine Jinkui Shenqi Pill on Adrenal Insufficiency after Acute Glucocorticoid Withdrawal in Rats. Journal of Proteome Research. 2016,15(7):2327-2336 .
    15. Feng Zheng, Biao Zhang, Yanan Sun, Mingfeng Qiu*, Jing Su. Evaluation of WO 2011045166 A1, FKBP52-Tau Interaction as novel therapeutical target for treating the neurological disorders involving Tau dysfunction. Expert Opinion on Therapeutic Patents, 2015,25(7):831-835.
    16. Haimiao Zou, Biao Zhang, Xinchun Xu, Jing Su, Yanan Sun, Song Xue, Xiaoyan Wang, Mingfeng Qiu*. Urinary metabolomic Strategy to evaluate Compound Danshen Dripping Pills for myocardial ischaemia in rats. Journal of Pharmaceutical and Biomedical Analysis, 2015, 112: 98-105.
    17. Qing Lin, Yunpeng Cai, Mingfeng Qiu*, Jing Su*, and Weien Yuan. Development 5-fluorouracil-loaded PLGA microspheres using a solid-in-oil-in-hydrophilic oil (S/O/Oh)novel method for treatment of tumor, Oncology Reports. 2014,32(6):2405-2410.
    18. Linjing Zhao, Hongbing Wu, Aihua Zhao, Huili Lu, Wei Sun, Chungwah Ma, Yiting Yang, Xue Xin, Haimiao Zou, Mingfeng Qiu*, Wei Jia*. The in vivo and in vitro study of polysaccharides from a two-herb formula on ulcerative colitis and potential mechanism of action. Journal of Ethnopharmacology, 2014,153,(1): 151-159.
    19. Hongmei An, Guowen Li, Chen Lin, Chao Gu, Miao Jin, Wenxian Sun, Ming feng Qiu*, Bing Hu. Acorus Tatarinowii Schott extract protects PC12 cells from Amyloid-β induced neurotoxicity. Pharmazie, 2014, 69(5): 391-395.
    20. Xue Xin, Haimiao Zou, Ningning Zheng, Xinchun Xu,Yinmin Liu, Xiaoxian Wang, Hongbing Wu, Lina Lu,Jing Su, Mingfeng Qiu*, Xiaoyan Wang. Metabonomic strategy to study the evaluation of Chinese Medicine Compound Danshen Dripping Pills interfering myocardial ischemia in rats. Evidence-Based Complementary and Alternative Medicine. 2013, 2013:1-10.
    21. Linjing Zhao1, Hongbing Wu1, Mingfeng Qiu1, Wei Sun, Runmin Wei, Xiaojiao Zheng, Yiting Yang, Xue Xin, Haimiao Zou, Tianlu Chen, Jiajian Liu, Lina Lu, Jing Su, Chungwah Ma, Aihua Zhao, Wei Jia. Metabolic Metabolic Signature of the Kidney Yang Deficiency Syndrome and Protective Effects of Two Herb Extracts in Rats GC/TOF MS. Evidence-Based Complementary and Alternative Medicine. 2013, 2013:1-10.
    22. Tie Zhao, Mingfeng Qiu*, Guoxiang Xie, Hongbing Wu, Wei Jia. Gender differences in the bioavailablility and pharmacokinetics of γ-schisndrin from a Wurenchun-PVP k30 solid dispersion in rats. Asian Journal of Traditional Medicines, 2010, 5(6): 51-59.
    23. Guoxiang Xie, Mao Ye, Yungang Wang, Yan Ni, Mingming Su, Hua Huang, Mingfeng Qiu*, Aihua Zhao, Xiaojiao Zheng, Tianlu Chen, Deborah E. Kipp, and Wei Jia*. Characterization of Pu-erh Tea using Chemical and Metabolic Profiling Approaches. J Agric Food Chem. 2009, 57(8): 3046-3054 .
    24. Ming-feng Qiu, Wei Jia, Shaoshun Li, Zhaohui Xu, Xia Sun, Xiaorong Wang, Yongyu Zhang, Guoxiang Xie. A New Silymarin Preparation Using Solid Dispersion Technique, Advances in Therapy, 2005,22 (6): 595-600.
    三、专利
    1. 发明专利名称:一种用于治疗慢性肾炎的肾茶总酚及其制备方法.申请号201510136874.4,授权公告日:2019-02-01,授权公告号:104739923,专利号:ZL 201510136874.4授权.发明人:邱明丰、苏靖、辛雪、薛松、郑峰、孙雅楠
    2. 发明专利名称:用于慢性肾炎的肾茶正丁醇部位药及其制备方法.申请号201110285928.5,授权公告日:2013-6-19,授权公告号:CN102309542B,专利号:ZL 201110285928.5授权,发明人:邱明丰、彭崇胜、殷明、王泽剑、张丽丽专利号:
    3. 发明专利名称:中药牛蒡子软胶囊制剂及其制备方法.申请号200910056330.1,授权公告日:2011-4-16,授权公告号:CN101618056B,专利号:ZL 200910056330.1授权,发明人:徐朝晖、邱明丰、翟秀华、贾伟
    4. 发明专利名称:三七不定根的诱导及组织培养的方法.申请号200610030608.4,授权公告日:2010-05-12,授权公告号:CN1947498B,专利号:ZL200610030608.4授权,发明人:贾伟、高先富、邱明丰、赵爱华、梁梦奇、谢国祥
    5. 发明专利名称:麻黄总生物碱与地龙酸性部位组合物及其制备方法.申请号200610026427.4,授权公告日:2009-2-9,授权公告号:CN100457126C,发明人:贾伟、苏明明、褚襄萍、徐朝晖、邱明丰
    6. 发明专利名称:从三七中提取三七素的方法.申请号200610027962.1. 授权公告日:2007-9-12,授权公告号:CN100336801C,专利号:ZL 200610027962.1授权,发明人:贾伟、邱明丰、谢国祥、赵爱华
    7. 发明专利名称:用于治疗咳喘病的麻黄与地龙组合物及其制备方法.申请号200610023458.4,授权公告日:2008-7-23,授权公告号:CN100404037C,专利号:ZL 200610023458.4授权,发明人:贾伟、徐朝晖、邱明丰、褚襄萍
    8. 发明专利名称:用于治疗妇女痛经的药物及其制备方法.申请号200510025931.8,授权公告日:2007-10-24 ,授权公告号:CN1003,44299C,专利号:ZL 2005 1 0025931.8,发明人:邱明丰、贾伟、刘金星、王小荣、赵爱华
    9. 发明专利名称:用于心脑血管疾病的红景天苷注射液及其制备方法.申请号200510025932.2,授权公告日:2007-9-19授权,授权公告号:CN100337633C,专利号:ZL 200510025932.2授权,发明人:贾伟、赵爱华、邱明丰、谢国祥

    6、联系方式
    邱明丰,上海交通大学药学院7号楼207室-208室

  • 联系方式

    Tel:86-21-3420 4052
    Email:mfqiu@sjtu.edu.cn

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